Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992191 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL1070289 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL1067810 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL1991256 | 0.75 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL11277506 | 0.74 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL9031055 | 0.72 | EDNRB (0.40) | SMN1; SMN2L3MBTL1ALDH1A1LMNAKDM4E | |
| SCHEMBL23599720 | 0.72 | HTR2C (0.46) | ALDH1A1HTR2CKDM4EMEN1MAPK1 | |
| SCHEMBL30598372 | 0.72 | TUBB3 (0.49) | SMN1; SMN2ALDH1A1LMNAHTR2CKDM4E | |
| SCHEMBL30647979 | 0.71 | POLB (0.50) | SMN1; SMN2L3MBTL1ALDH1A1POLBMEN1 | |
| SCHEMBL12479725 | 0.71 | LMNA (0.52) | SMN1; SMN2ALDH1A1LMNAKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2013-11-28 | — | — | US | disclosed |
| US-8349843-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2012-04-12 | — | — | US | disclosed |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBOTT GMBH & CO. KG (DE) | 2011-07-21 | — | — | US | disclosed |
| US-RE42477-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-21 | — | — | US | disclosed |
| US-RE42462-E1 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-14 | — | — | US | disclosed |
| US-7863445-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-03-25 | — | — | US | disclosed |
| US-7601730-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2009-10-13 | — | — | US | disclosed |
| US-7582647-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2009-09-01 | — | — | US | disclosed |
| US-20040092742-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG | 2004-05-13 | — | — | US | disclosed |
| US-6600043-B2 | Pyramidine or triazine derivatives which specifically inhibit the binding of endothelin to the receptor | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2002-05-02 | — | — | US | disclosed |
| EP-0785926-B1 | CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | BASF AG (DE) | 2001-08-22 | — | — | EP | disclosed |
| EP-1110952-A1 | Carboxylic acid derivates, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-27 | — | — | EP | disclosed |
| US-6197958-B1 | CYCLOPENTAPYRIMIDINE DERIVATIVES; ENDOTHELIN RECEPTOR INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-06 | — | — | US | disclosed |
| US-5969134-A | CARDIOVASCULAR DISORDERS, VASOCONSTRICTION, HYPOTENSIVE AGENTS AND RELEASE OF ENDOTHELINS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5932730-A | Carboxylic acid derivatives, their preparation and use | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-03 | — | — | US | disclosed |
| EP-0785926-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011914-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1996-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088911-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | SMN1; SMN2 2110/4885L3MBTL1 1562/4885ALDH1A1 414/4885 |
| US-20020052495-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, SUCNR1 | SMN1; SMN2 2020/4885L3MBTL1 1897/4885ALDH1A1 189/4885 |
| US-20130317044-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | SMN1; SMN2 2408/4885L3MBTL1 1633/4885ALDH1A1 348/4885 |
| US-20040092742-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, SUCNR1 | SMN1; SMN2 2020/4885L3MBTL1 1897/4885ALDH1A1 189/4885 |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | SMN1; SMN2 2408/4885L3MBTL1 1633/4885ALDH1A1 348/4885 |
| US-20110178294-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | SMN1; SMN2 2408/4885L3MBTL1 1633/4885ALDH1A1 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.