Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690399 | 0.88 | HCRTR1 (0.44) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10693538 | 0.85 | P2RX7 (0.43) | LMNAL3MBTL1MEN1KMT2AP2RX7 | |
| SCHEMBL10691721 | 0.83 | LMNA (0.53) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL11094846 | 0.83 | L3MBTL1 (0.43) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10688317 | 0.83 | HPGD (0.45) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10685551 | 0.77 | HPGD (0.43) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL11005245 | 0.76 | EHMT2 (0.42) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL3231318 | 0.76 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHPGDHCRTR1 | |
| SCHEMBL10690202 | 0.75 | L3MBTL1 (0.46) | ALDH1A1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10690788 | 0.74 | ITGB1 (0.41) | ALDH1A1LMNAL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4476311-A | Analgesic 4-carboxy-pyrrolidin-2-one compound | THE PURDUE FREDERICK COMPANY (US) | 1984-10-09 | — | — | US | claimed |
| US-4731457-A | 1-substituted, 2,3-diphenyl-3-hydroxymethyl pyrrolidines, where the 2- and/or 3-phenyl can be substituted | THE PURDUE FREDERICK COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| US-4639529-A | Analgesic and anti-inflammatory compounds | THE PURDUE FREDERICK COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| US-4476311-A | Analgesic 4-carboxy-pyrrolidin-2-one compound | THE PURDUE FREDERICK COMPANY (US) | 1984-10-09 | — | — | US | disclosed |