Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688516 | 0.85 | ALDH1A1 (0.44) | P2RX7KMT2ALMNAMEN1L3MBTL1 | |
| SCHEMBL10692607 | 0.80 | KMT2A (0.56) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL10690399 | 0.76 | HCRTR1 (0.44) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL31467338 | 0.73 | KMT2A (0.46) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL29283299 | 0.73 | KMT2A (0.46) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL25029977 | 0.73 | KMT2A (0.46) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL31139900 | 0.73 | KMT2A (0.46) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL29283296 | 0.73 | KMT2A (0.46) | KMT2ACA1CA2CA4CA7 | |
| SCHEMBL11094846 | 0.71 | L3MBTL1 (0.43) | P2RX7KMT2ALMNAMEN1POLB | |
| SCHEMBL10691721 | 0.68 | LMNA (0.53) | KMT2ALMNAMEN1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731457-A | 1-substituted, 2,3-diphenyl-3-hydroxymethyl pyrrolidines, where the 2- and/or 3-phenyl can be substituted | THE PURDUE FREDERICK COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| US-4639529-A | Analgesic and anti-inflammatory compounds | THE PURDUE FREDERICK COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| US-4476311-A | Analgesic 4-carboxy-pyrrolidin-2-one compound | THE PURDUE FREDERICK COMPANY (US) | 1984-10-09 | — | — | US | disclosed |