Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | MGAM | O43451 | 3/20 | 0.36 |
| ▸ | SI | P14410 | 3/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688930 | 0.91 | MEN1 (0.39) | PDE5AFTOKMT2AMEN1LMNA | |
| SCHEMBL10689035 | 0.89 | ESR1 (0.42) | PDE5AGAAFTOKMT2AMEN1 | |
| SCHEMBL10689239 | 0.83 | PDE5A (0.45) | PDE5AFTOPDE4APDE4BPDE4C | |
| SCHEMBL10613330 | 0.82 | PDE5A (0.37) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10689009 | 0.81 | PDE5A (0.39) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10686647 | 0.79 | PDE2A (0.42) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL10690574 | 0.76 | PDE2A (0.51) | PDE5AGAAHTT | |
| SCHEMBL10690513 | 0.75 | AMY1A (0.47) | PDE5AKMT2AMEN1HTTHSD17B10 | |
| SCHEMBL10692316 | 0.74 | PDGFRB (0.43) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL10688934 | 0.73 | PDE5A (0.43) | PDE5AGAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |