Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690574 | 0.86 | PDE2A (0.51) | AMY1APDE5APDE3BPDE3AALDH1A1 | |
| SCHEMBL10689035 | 0.85 | ESR1 (0.42) | AMY1APDE5APDE3BPDE3AMEN1 | |
| SCHEMBL10690462 | 0.83 | AMY1A (0.40) | AMY1APDE5APDE3BPDE3AALDH1A1 | |
| SCHEMBL11356780 | 0.82 | AMY1A (0.47) | AMY1AADORA2BHSP90AA1HSP90AB1PDE5A | |
| SCHEMBL10690518 | 0.80 | AMY1A (0.47) | AMY1AADORA2BHSP90AA1HSP90AB1PDE5A | |
| SCHEMBL10610355 | 0.79 | PDE2A (0.40) | PDE5APDE3BPDE3ACYP1A2CYP3A4 | |
| SCHEMBL10685926 | 0.78 | PDGFRB (0.48) | HSP90AA1CYP3A4MAPK1PDE2APDGFRB | |
| SCHEMBL10870043 | 0.78 | MAPT (0.37) | AMY1APDE5AALDH1A1 | |
| SCHEMBL10686647 | 0.77 | PDE2A (0.42) | AMY1AMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10688260 | 0.77 | NR1I2 (0.34) | AMY1AMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |