SCHEMBL10690020

SCHEMBL10690020

O=Cc1cccc(CCc2cccnc2)c1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.49
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2A6 P11509 1/20 0.46
TBXAS1 P24557 6/20 0.46
HRH4 Q9H3N8 1/20 0.45
HRH3 Q9Y5N1 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
HRH1 P35367 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene SCHEMBL10685834 0.83 TDP1 (0.39) CHRNA7CYP1A2CYP2D6TBXAS1TDP1
SCHEMBL10681531 0.83 CHRNA7 (0.52) CHRNA7CYP1A2CYP2D6CYP2A6TBXAS1
SCHEMBL5020713 0.78 MAOA (0.56) CYP2A6
SCHEMBL29485692 0.78 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6CYP2A6TBXAS1
SCHEMBL724866 0.78 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6CYP2A6TBXAS1
SCHEMBL25263445 0.77 CYP1A2 (0.48) CHRNA7CYP1A2CYP2D6CYP2A6TBXAS1
SCHEMBL9035635 0.77 MAOA (0.68) TDP1
SCHEMBL5915884 0.77 LTA4H (0.60) CYP1A2CYP2D6L3MBTL1
SCHEMBL12062568 0.76 PLOD2 (0.48) CYP1A2CYP2D6TBXAS1TDP1
SCHEMBL18003428 0.76 DAO (0.47) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4745120-A CARDIOYASCULAR DISORDERS, ANTICOAGULANTS HOECHST AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed
EP-0173172-A2 3-Pyridyl compounds and process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1986-03-05 EP disclosed