SCHEMBL10690287

SCHEMBL10690287

FC(F)(F)Oc1cccc2c1nc(C(F)(F)F)n2SC(F)(Cl)Cl

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 2/20 0.32
SLC40A1 Q9NP59 1/20 0.31
HSD11B1 P28845 1/20 0.30
MPL P40238 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B13 Q7Z5P4 1/20 0.30
SCN5A Q14524 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10691766 0.89
SCHEMBL10690283 0.87 LMNA (0.30)
SCHEMBL10696194 0.85 PDE2A (0.35) KDM4E
SCHEMBL10696207 0.83 SCN5A (0.32) SCN5A
SCHEMBL10692362 0.82 SCN5A (0.36) SCN5A
SCHEMBL10693016 0.79 HSD17B13 (0.33) HSD11B1MPLKDM4EALDH1A1HPGD
SCHEMBL10696167 0.76 PGK1 (0.32)
SCHEMBL10695942 0.73 ALDH1A1 (0.48) KDM4EALDH1A1HPGD
SCHEMBL10695710 0.72 PDE10A (0.39) F2RL3KDM4EALDH1A1HPGDSCN5A
SCHEMBL10693333 0.71 IDH1 (0.36) F2RL3SCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251012-A2 N-sulfenyl-2-trifluoromethyl benzimidazoles BAYER AG (DE) 1988-01-07 EP disclosed