Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691911 | 0.84 | PKM (0.38) | CYP1A2PDE3BPDE3APDE5A | |
| SCHEMBL10690574 | 0.84 | PDE2A (0.51) | AMY1ACYP1A2KDM4EALDH1A1PDE3B | |
| SCHEMBL10689035 | 0.83 | ESR1 (0.42) | AMY1APOLBPDE3BPDE3APDE5A | |
| SCHEMBL10690513 | 0.83 | AMY1A (0.47) | AMY1ACYP1A2ALDH1A1PDE3BPDE3A | |
| SCHEMBL10688260 | 0.80 | NR1I2 (0.34) | AMY1ASMN1; SMN2CYP1A2KDM4EALDH1A1 | |
| SCHEMBL10686151 | 0.78 | EGFR (0.35) | AMY1ASMN1; SMN2POLBCYP1A2KDM4E | |
| SCHEMBL10691944 | 0.77 | GUSB (0.38) | AMY1ASMN1; SMN2KDM4EALDH1A1PDE5A | |
| SCHEMBL10610355 | 0.77 | PDE2A (0.40) | CYP1A2KDM4EPDE3BPDE3APDE5A | |
| SCHEMBL10690472 | 0.77 | PDE2A (0.43) | AMY1ACYP1A2KDM4EALDH1A1QPCT | |
| SCHEMBL10685926 | 0.76 | PDGFRB (0.48) | POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |