Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686293 | 0.78 | GRIN2D (0.42) | AMY1AKMT2APDE5AKDM4EHSD17B10 | |
| SCHEMBL10691571 | 0.76 | PDE2A (0.41) | KMT2APDE5AAURKAKDM4EHSD17B10 | |
| SCHEMBL10692415 | 0.76 | KDM4E (0.41) | SMN1; SMN2MAPTPDE5AKDM4EHTT | |
| SCHEMBL10743332 | 0.76 | PDE5A (0.45) | NPC1RAB9AHSP90AA1PKMAMY1A | |
| SCHEMBL10688852 | 0.75 | ADORA2B (0.45) | NPC1RAB9AHSP90AA1PKMSMN1; SMN2 | |
| SCHEMBL10691322 | 0.74 | PDE5A (0.43) | SMN1; SMN2KMT2APDE5AKDM4EHTT | |
| SCHEMBL7272224 | 0.74 | PDE5A (0.52) | NPC1RAB9AHSP90AA1PKMAMY1A | |
| SCHEMBL10686340 | 0.74 | NPC1 (0.40) | NPC1RAB9AHSP90AA1PKMAMY1A | |
| SCHEMBL11783925 | 0.74 | PDE5A (0.67) | KMT2APDE5AAURKAKDM4EHSD17B10 | |
| SCHEMBL10690686 | 0.74 | EGLN2 (0.39) | KMT2APDE5AKDM4EHSD17B10PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |