Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CCND1 | P24385 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | CCND3 | P30281 | 7/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686791 | 0.88 | MEN1 (0.40) | ESR2PDE5AKMT2AKDM4EMEN1 | |
| SCHEMBL10692084 | 0.86 | PDE5A (0.44) | PDE2APDE5AKMT2AKDM4EMEN1 | |
| SCHEMBL10689310 | 0.84 | MKNK1 (0.47) | — | |
| SCHEMBL10610755 | 0.82 | ESR1 (0.43) | PDE2AESR1ESR2CDK4CCNA2 | |
| SCHEMBL10690686 | 0.82 | EGLN2 (0.39) | PDE2APDE5APDE3BPDE3AKMT2A | |
| SCHEMBL10692555 | 0.81 | CA2 (0.43) | PDE2APDE5APDE3BPDE3AKMT2A | |
| SCHEMBL10690895 | 0.81 | TAS2R14 (0.40) | PDE2APDE5APDE3BPDE3AKMT2A | |
| SCHEMBL10686293 | 0.80 | GRIN2D (0.42) | PDE2APDE5APDE3BPDE3AKMT2A | |
| SCHEMBL10692548 | 0.80 | MAPT (0.46) | PDE2ACCNA2CDK2PDE5APDE3B | |
| SCHEMBL10685094 | 0.78 | PDE2A (0.46) | PDE2APDE5APDE3BPDE3AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |