Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691571 | 0.80 | PDE2A (0.41) | PDE3BPDE3APDE2AHPSEPDE5A | |
| SCHEMBL10692555 | 0.79 | CA2 (0.43) | PDE3BPDE3APDE2APDE5AKDM4E | |
| SCHEMBL10690982 | 0.78 | NPC1 (0.37) | AMY1APDE3BPDE3APDE5AKDM4E | |
| SCHEMBL10690686 | 0.77 | EGLN2 (0.39) | GRIN1GRIN2BPDE3BPDE3APDE2A | |
| SCHEMBL10689310 | 0.76 | MKNK1 (0.47) | — | |
| SCHEMBL10687815 | 0.76 | EGFR (0.37) | AMY1APDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10690895 | 0.76 | TAS2R14 (0.40) | PDE3BPDE3APDE2APDE5AKDM4E | |
| SCHEMBL10692415 | 0.75 | KDM4E (0.41) | GRIN1GRIN2BPDE3BPDE3APDE2A | |
| SCHEMBL10692548 | 0.75 | MAPT (0.46) | PDE3BPDE3APDE2APDE5AKDM4E | |
| SCHEMBL10691322 | 0.73 | PDE5A (0.43) | PDE3BPDE3APDE5AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727082-A | CARDIOVASCULAR DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |