Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 7/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691322 | 0.91 | PDE5A (0.43) | KDM4EHTTHSD17B10SMN1; SMN2PDE5A | |
| SCHEMBL10685094 | 0.91 | PDE2A (0.46) | KDM4EHSD17B10SMN1; SMN2PDE5ACTSG | |
| SCHEMBL10691950 | 0.78 | PDE2A (0.45) | KDM4EHTTHSD17B10SMN1; SMN2PDE5A | |
| SCHEMBL10686791 | 0.78 | MEN1 (0.40) | KDM4EHSD17B10SMN1; SMN2PDE5AGAA | |
| SCHEMBL10690982 | 0.76 | NPC1 (0.37) | KDM4EHTTHSD17B10SMN1; SMN2PDE5A | |
| SCHEMBL10686293 | 0.75 | GRIN2D (0.42) | KDM4EHSD17B10PDE5APDE2AGRIN1 | |
| SCHEMBL10691944 | 0.74 | GUSB (0.38) | KDM4EHTTHSD17B10SMN1; SMN2PDE5A | |
| SCHEMBL10691571 | 0.73 | PDE2A (0.41) | KDM4EHSD17B10PDE5APDE2AGAA | |
| SCHEMBL10690686 | 0.70 | EGLN2 (0.39) | KDM4EHSD17B10PDE5APDE2AGRIN1 | |
| SCHEMBL11713584 | 0.70 | ALDH1A1 (0.52) | KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |