Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1453376 | 0.78 | MAOA (0.41) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL1226276 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL19458653 | 0.76 | LMNA (0.41) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL1713865 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL9690804 | 0.72 | MAPK1 (0.37) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL7975341 | 0.72 | ALDH1A1 (0.40) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL343269 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL777177 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL2392316 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 | |
| SCHEMBL3911663 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTHPGDMGLLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4792550-A | THROMBOXANE ANTAGONIST-HYPOTENSIVE AGENT; CARDIOVASCULAR, NERVOUS SYSTEM DISORDERS; ANTIALLERGENS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-12-20 | — | — | US | disclosed |
| EP-0171146-B1 | 13-AZA-14-OXO-TXA2 ANALOGUES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-09-28 | — | — | EP | disclosed |
| EP-0171146-A1 | 13-Aza-14-oxo-txa2 analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1986-02-12 | — | — | EP | disclosed |