SCHEMBL1453376

SCHEMBL1453376

[CH2]C(C)Sc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
MGLL Q99685 1/20 0.41
HSD17B10 Q99714 1/20 0.41
LMNA P02545 2/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
SLC6A4 P31645 1/20 0.36
ALDH1A1 P00352 3/20 0.36
MAPK1 P28482 2/20 0.36
KDM4E B2RXH2 3/20 0.36
GAA P10253 2/20 0.36
PKM P14618 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
POLB P06746 1/20 0.34
PTPN1 P18031 1/20 0.33
CDC25A P30304 1/20 0.33
CDC25B P30305 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10691015 0.78 SMN1; SMN2 (0.45) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL343269 0.78 SMN1; SMN2 (0.45) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL5173197 0.78 SMN1; SMN2 (0.45) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL1453001 0.78 SMN1; SMN2 (0.45) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL1713865 0.77 SMN1; SMN2 (0.50) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL315823 0.77 HSD17B10 (0.48) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL8744335 0.77 GAA (0.39) MAOAMAOBSMN1; SMN2MAPTHPGD
Fluoride SCHEMBL1336886 0.76 MAOA (0.48) MAOAMAOBSMN1; SMN2MAPTHPGD
Fluoride SCHEMBL27856329 0.76 MAOA (0.48) MAOAMAOBSMN1; SMN2MAPTHPGD
SCHEMBL21382360 0.75 LMNA (0.40) MAOAMAOBSMN1; SMN2MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7910617-B2 Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound SANKYO COMPANY, LIMITED (JP) 2011-03-22 US disclosed
US-20100273650-A1 Fungicidal Mixtures Comprising a Substituted 3-Hydroxymethylpyridine and a Further Fungicidal Compound BASF SE (DE) 2010-10-28 US disclosed
US-20100267555-A1 Fungicidal mixtures II BASF SE (DE) 2010-10-21 US disclosed
EP-2230909-A2 FUNGICIDAL MIXTURES COMPRISING A SUBSTITUTED 3-HYDROXYMETHYLPYRIDINE AND A FURTHER FUNGICIDAL COMPOUND BASF SE (DE) 2010-09-29 EP disclosed
WO-2010103065-A1 FUNGICIDAL COMPOSITIONS AND THEIR USE BASF SE (DE) 2010-09-16 WO disclosed
EP-2222169-A2 FUNGICIDAL MIXTURES II BASF SE (DE) 2010-09-01 EP disclosed
WO-2009063075-A2 FUNGICIDAL MIXTURES II BASF SE (DE) 2009-05-22 WO disclosed
WO-2009063074-A2 FUNGICIDAL MIXTURES I BASF SE (DE) 2009-05-22 WO disclosed
US-20070191468-A1 Amino alcohol compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2007-08-16 US disclosed
EP-1733724-A1 AMINO ALCOHOL COMPOUND Sankyo Company, Limited (JP) 2006-12-20 EP disclosed
EP-0628026-B1 CYANO-OXIME ETHERS, PROCESS FOR PRODUCING THEM, AGENTS CONTAINING THEM AND THEIR USE BASF AG (DE) 1997-01-22 EP disclosed
EP-0628026-A1 CYANO-OXIME ETHERS, PROCESS FOR PRODUCING THEM, AGENTS CONTAINING THEM AND THEIR USE. BASF AG (DE) 1994-12-14 EP disclosed
WO-1993016985-A1 CYANO-OXIME ETHERS, PROCESS FOR PRODUCING THEM, AGENTS CONTAINING THEM AND THEIR USE BASF AKTIENGESELLSCHAFT (DE) 1993-09-02 WO disclosed
US-4517003-A N-acyl phosphoric triamide urease inhibitors and urease inhibited urea based fertilizer compositions ALLIED CORPORATION (US) 1985-05-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100267555-A1 Fungicidal mixtures II CBR3, CBR1, NOX3 MAOA 1028/4885MAOB 1498/4885SMN1; SMN2 3685/4885
US-20070191468-A1 Amino alcohol compound ADH1A, ADH1C, BCAT1 MAOA 2055/4885MAOB 1138/4885SMN1; SMN2 1845/4885
US-20100273650-A1 Fungicidal Mixtures Comprising a Substituted 3-Hydroxymethylpyridine and a Further Fungicidal Compound CBR3, NOX3, CBR1 MAOA 821/4885MAOB 941/4885SMN1; SMN2 2748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.