Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689786 | 0.85 | SIGMAR1 (0.52) | MAPTRXFP1TRPA1SIGMAR1S1PR2 | |
| SCHEMBL6686632 | 0.85 | SIGMAR1 (0.52) | MAPTRXFP1TRPA1SIGMAR1S1PR2 | |
| SCHEMBL6685308 | 0.85 | SIGMAR1 (0.52) | MAPTRXFP1TRPA1SIGMAR1S1PR2 | |
| SCHEMBL6686320 | 0.83 | MAOA (0.52) | MAPTRXFP1TRPA1SIGMAR1MAOA | |
| SCHEMBL10694052 | 0.79 | TRPA1 (0.56) | MAPTRXFP1TRPA1S1PR2S1PR4 | |
| SCHEMBL1678621 | 0.79 | ALOX5 (0.53) | MAPTRXFP1TRPA1SIGMAR1ALOX5 | |
| SCHEMBL8095284 | 0.79 | SIGMAR1 (0.71) | MAPTRXFP1SIGMAR1MAOAMAOB | |
| SCHEMBL2823250 | 0.79 | SIGMAR1 (0.71) | MAPTRXFP1SIGMAR1MAOAMAOB | |
| SCHEMBL6546948 | 0.79 | SIGMAR1 (0.71) | MAPTRXFP1SIGMAR1MAOAMAOB | |
| SCHEMBL8094527 | 0.79 | SIGMAR1 (0.71) | MAPTRXFP1SIGMAR1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727073-A | CEREBOVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0177287-A2 | Pyrimidine derivatives, processes for preparation thereof and composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-04-09 | — | — | EP | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |