Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.41 |
| ▸ | WNT3A | P56704 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GNG2 | P59768 | 1/20 | 0.38 |
| ▸ | GNB1 | P62873 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688073 | 0.92 | HSD17B3 (0.45) | HSD17B3CTNNB1WNT3APDE4APDE4B | |
| SCHEMBL25569790 | 0.91 | HPGD (0.47) | HPGDRAB9AALDH1A1MAPTHSD17B3 | |
| SCHEMBL7084031 | 0.91 | HSD17B3 (0.47) | ALDH1A1MAPTHSD17B3MEN1KMT2A | |
| SCHEMBL10693463 | 0.88 | ATM (0.42) | HPGDRAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL10779070 | 0.84 | ATM (0.41) | HPGDRAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL10693207 | 0.82 | GNG2 (0.45) | ALDH1A1MAPTCTNNB1WNT3AGNG2 | |
| SCHEMBL7085094 | 0.82 | HSD17B3 (0.49) | HSD17B3 | |
| SCHEMBL8102062 | 0.81 | ALDH1A1 (0.39) | HPGDRAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL4694745 | 0.80 | MAPT (0.47) | HPGDRAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL25569823 | 0.79 | HPGD (0.47) | HPGDRAB9AALDH1A1MAPTHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791104-A | HYPOTENSIVE, ANTILIPEMIC, ANTIHROMBOTIC, ANTIHYPOXIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1988-12-13 | — | — | US | disclosed |
| WO-1987002359-A1 | DIHYDROBENZOTHIOPHENE AND THIOCHROMANE AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-04-23 | — | — | WO | disclosed |