Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CDC25C | P30307 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691731 | 0.86 | TRIM24 (0.44) | TRIM24CDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL10698922 | 0.85 | HDAC1 (0.42) | PARP1KMT2AGAACNR2TDP1 | |
| SCHEMBL10700479 | 0.85 | ALDH1A1 (0.46) | PARP1KMT2AGAACNR2TDP1 | |
| SCHEMBL10695099 | 0.84 | MEN1 (0.48) | TRIM24CDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL10699753 | 0.82 | KDM4E (0.41) | PARP1KMT2AGAACNR2TDP1 | |
| SCHEMBL10698291 | 0.81 | HDAC1 (0.42) | PARP1GAACNR2CHEK2ALDH1A1 | |
| SCHEMBL10694299 | 0.78 | CYP11B1 (0.54) | TRIM24CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL10699168 | 0.76 | SLC2A1 (0.49) | PARP1HTTKMT2AGAAMEN1 | |
| SCHEMBL10697210 | 0.74 | CA12 (0.51) | TRIM24HTTKMT2AGAAMEN1 | |
| SCHEMBL10700878 | 0.74 | POLB (0.40) | PARP1KMT2AGAAMEN1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |