Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLI1 | P08151 | 5/20 | 0.69 |
| ▸ | GLI2 | P10070 | 5/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.58 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877576 | 0.80 | PTGS1 (0.69) | GLI1GLI2PTGS1PTGS2MAPT | |
| SCHEMBL10692939 | 0.80 | ALOX5 (1.00) | GLI1GLI2ALOX5SMN1; SMN2KMT2A | |
| SCHEMBL10694238 | 0.75 | ALOX5 (0.76) | ALOX5PTGS1PTGS2CXCR1CXCR2 | |
| R-Ketoprofen SCHEMBL195303 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| R-Ketoprofen SCHEMBL29353694 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL3843886 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL679920 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL16757741 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL8754790 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL29396875 | 0.75 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196674-A2 | Hydroxamates as modulators of arachidonic acid metabolic pathways | USV PHARMACEUTICAL CORPORATION (US) | 1986-10-08 | — | — | EP | claimed |
| US-4792560-A | ANTIALLERGENS; ANTIINFLAMMATORY AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0196674-A2 | Hydroxamates as modulators of arachidonic acid metabolic pathways | USV PHARMACEUTICAL CORPORATION (US) | 1986-10-08 | — | — | EP | disclosed |