Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691138 | 0.82 | GABRA1 (0.49) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10691683 | 0.78 | HPGD (0.44) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10693964 | 0.78 | GABRA1 (0.54) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10694413 | 0.76 | MAPK1 (0.45) | LMNAMAPK1 | |
| SCHEMBL11826946 | 0.76 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL22591849 | 0.75 | GABRA1 (0.38) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11826107 | 0.73 | GABRA1 (0.48) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| Hydrochloric Acid SCHEMBL8933498 | 0.71 | GABRA1 (0.47) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL22591839 | 0.71 | CYP11B2 (0.40) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL22591851 | 0.71 | CYP11B2 (0.42) | GABRA1GABRA5GABRA2GABRB2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |