Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11832211 | 0.84 | GABRA5 (0.51) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11826946 | 0.84 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11809246 | 0.84 | OPRK1 (0.69) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10693964 | 0.84 | GABRA1 (0.54) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL7318994 | 0.83 | GABRA1 (0.71) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10692497 | 0.82 | IKBKB (0.43) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL10691683 | 0.82 | HPGD (0.44) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11835751 | 0.82 | GABRA1 (0.49) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11826107 | 0.81 | GABRA1 (0.48) | GABRA1GABRA5GABRA2GABRB2OPRK1 | |
| SCHEMBL11826392 | 0.81 | GABRA1 (0.59) | GABRA1GABRA5GABRA2GABRB2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |