Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694252 | 0.87 | GABRA1 (0.58) | HPGDKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL10691138 | 0.82 | GABRA1 (0.49) | HPGDALDH1A1GABRA5GABRA2GABRA1 | |
| SCHEMBL8933539 | 0.78 | GABRA1 (0.47) | HPGDKDM4EALDH1A1GABRA5GABRA2 | |
| SCHEMBL10694413 | 0.76 | MAPK1 (0.45) | ALDH1A1LMNA | |
| SCHEMBL10692488 | 0.76 | GABRA1 (0.62) | HPGDALDH1A1GABRA5GABRA2GABRA1 | |
| SCHEMBL11809246 | 0.76 | OPRK1 (0.69) | HPGDKDM4ETP53GABRA5GABRA2 | |
| SCHEMBL11832211 | 0.76 | GABRA5 (0.51) | HPGDGABRA5GABRA2GABRA1GABRA3 | |
| SCHEMBL11826946 | 0.76 | GABRA1 (0.69) | HPGDKDM4EALDH1A1GABRA5GABRA2 | |
| SCHEMBL11835751 | 0.74 | GABRA1 (0.49) | HPGDGABRA5GABRA2GABRA1GABRA3 | |
| SCHEMBL11837344 | 0.73 | LMNA (0.62) | HPGDMAPTGABRA5GABRA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |