Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10689170 | 0.81 | ADRA1A (0.40) | TSHRHTTMAPTKDM4EMAPK1 | |
| SCHEMBL10694392 | 0.80 | NPC1 (0.47) | NOTUMTSHRHTTPOLBMAPT | |
| SCHEMBL10695401 | 0.80 | RAD52 (0.42) | NOTUMTSHRHTTMAPTKDM4E | |
| SCHEMBL10692682 | 0.77 | NPC1 (0.47) | HTTMAPTKDM4ELMNAHCRTR1 | |
| SCHEMBL2470209 | 0.75 | NOTUM (0.46) | NOTUMTSHRHTTMAPTKDM4E | |
| SCHEMBL10694080 | 0.74 | NPC1 (0.45) | NPC1EHMT2 | |
| SCHEMBL15314930 | 0.71 | RAB9A (0.53) | TSHRHTTMAPTKDM4ELMNA | |
| SCHEMBL9590671 | 0.69 | NOTUM (0.44) | NOTUMTSHRHTTMAPTKDM4E | |
| SCHEMBL27019600 | 0.69 | EHMT2 (0.44) | NOTUMTSHRHTTMAPTKDM4E | |
| SCHEMBL10371341 | 0.68 | RAD52 (0.54) | TSHRMAPTKDM4ELMNAHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |