Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694392 | 0.86 | NPC1 (0.47) | NPC1MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL10695992 | 0.83 | SCN9A (0.39) | MAPTALDH1A1LMNAKDM4EHCRTR1 | |
| SCHEMBL10692622 | 0.83 | CNR1 (0.39) | BACE1LMNAEHMT2NR3C1AR | |
| SCHEMBL10695891 | 0.80 | OPRD1 (0.41) | NR3C1AR | |
| SCHEMBL10694080 | 0.80 | NPC1 (0.45) | NPC1EHMT2 | |
| SCHEMBL10694576 | 0.77 | POLB (0.33) | MAPTALDH1A1HSD17B10BACE1BCHE | |
| SCHEMBL10692536 | 0.77 | NOTUM (0.41) | NPC1MAPTALDH1A1MAPK1BACE1 | |
| SCHEMBL10693883 | 0.76 | BACE1 (0.44) | MAPTALDH1A1USP2ALOX15HSD17B10 | |
| SCHEMBL10368742 | 0.76 | RAD52 (0.44) | NPC1MAPTALDH1A1MAPK1USP2 | |
| SCHEMBL10692592 | 0.74 | BACE1 (0.44) | MAPTALDH1A1USP2ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |