Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305067 | 0.82 | HTT (0.49) | HTTSLC6A2SLC6A3HTR1ASLC6A4 | |
| SCHEMBL2975670 | 0.70 | HTT (0.47) | HTTSLC6A2SLC6A3HTR1ASLC6A4 | |
| SCHEMBL6327555 | 0.68 | CYP3A4 (0.47) | HTTSLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL7993157 | 0.68 | HTT (0.49) | HTTSLC6A2SLC6A3HTR1ASLC6A4 | |
| SCHEMBL10351845 | 0.67 | HTT (0.47) | HTTSLC6A2SLC6A3HTR1ASLC6A4 | |
| SCHEMBL7995324 | 0.67 | HTT (0.55) | HTTSLC6A2SLC6A3TSHRLMNA | |
| SCHEMBL6433409 | 0.67 | HTT (0.44) | HTTSLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL10296064 | 0.65 | MAOA (0.39) | HTR2AMAOBTDP1MAOASMN1; SMN2 | |
| SCHEMBL6469379 | 0.65 | TSHR (0.52) | HTTSLC6A2SLC6A3HTR1ATSHR | |
| SCHEMBL339813 | 0.64 | LMNA (0.82) | SLC6A2SLC6A3LMNACYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252353-A1 | 4-Benzyloxy-3-pyrrolin-2-one-1-yl-acetamide, preparation and use | LONZA AG (CH) | 1988-01-13 | — | — | EP | disclosed |