Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.59 |
| ▸ | PTAFR | P25105 | 9/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694618 | 0.89 | GABRA1 (0.56) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10698677 | 0.84 | GABRA1 (0.56) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10691840 | 0.83 | PTAFR (0.68) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL11681893 | 0.78 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10692488 | 0.78 | GABRA1 (0.62) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL9668954 | 0.77 | PTAFR (0.74) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Triazolam SCHEMBL29228 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL13352295 | 0.76 | GABRA1 (0.83) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| Triazolam SCHEMBL5142333 | 0.76 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRA3OPRK1 | |
| SCHEMBL10694341 | 0.76 | NPC1 (0.48) | PTAFRTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |