Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694618 | 0.96 | GABRA1 (0.56) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10694413 | 0.88 | MAPK1 (0.45) | LMNAFGFR1SRCHTR2APPARG | |
| SCHEMBL10693440 | 0.84 | GABRA1 (0.60) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL7318994 | 0.79 | GABRA1 (0.71) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10694270 | 0.79 | GABRA1 (0.62) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10694252 | 0.76 | GABRA1 (0.58) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10691840 | 0.74 | PTAFR (0.68) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11718805 | 0.72 | OPRK1 (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| Alprazolam SCHEMBL8398 | 0.72 | GABRA1 (1.00) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL8250450 | 0.72 | GABRA1 (0.74) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |