Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL4664594 | 0.84 | LMNA (0.53) | ALDH1A1TSHRFGFR4LMNAMEN1 | |
| Acrylamide SCHEMBL9476419 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TSHRFGFR4LMNAMEN1 | |
| Acrylamide SCHEMBL17200198 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TSHRFGFR4LMNAMEN1 | |
| Acrylamide SCHEMBL11189878 | 0.80 | — | — | |
| Tromethamine SCHEMBL6905131 | 0.80 | LMNA (0.71) | ALDH1A1LMNAMEN1KMT2ATP53 | |
| Acrylamide SCHEMBL28073867 | 0.77 | — | — | |
| Tromethamine SCHEMBL2021309 | 0.77 | MEN1 (0.67) | TSHRLMNAMEN1KMT2A | |
| Acrylamide SCHEMBL617584 | 0.77 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4LMNATP53 | |
| Acrylamide SCHEMBL371326 | 0.77 | — | — | |
| Acrylamide SCHEMBL1332245 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11851514-B2 | Inverse Ugelstad particles | LIFE TECHNOLOGIES AS (NO) | 2023-12-26 | — | — | US | disclosed |
| EP-3390025-B1 | REUSABLE LENS MOLDS AND METHODS OF USE THEREOF | ALCON INC (CH) | 2023-09-06 | — | — | EP | disclosed |
| EP-3325522-B1 | POLYMERIC PARTICLES | LIFE TECH AS (NO) | 2023-06-28 | — | — | EP | disclosed |
| EP-4161966-A1 | ANTI-BCMA ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-04-12 | — | — | EP | disclosed |
| US-20220056184-A1 | INVERSE UGELSTAD PARTICLES | LIFE TECHNOLOGIES AS (NO) | 2022-02-24 | — | — | US | disclosed |
| CN-113637116-A | Polymer particles | 生命科技公司 | 2021-11-12 | — | — | CN | disclosed |
| US-11130833-B2 | Inverse ugelstad particles | LIFE TECHNOLOGIES AS (NO) | 2021-09-28 | — | — | US | disclosed |
| CN-108026217-B | Polymer particles | 生命科技公司 | 2021-09-07 | — | — | CN | disclosed |
| US-20210139626-A1 | Inverse Ugelstad Particles | LIFE TECHNOLOGIES AS (NO) | 2021-05-13 | — | — | US | disclosed |
| US-10836854-B2 | Inverse Ugelstad particles | SINTEF (NO) | 2020-11-17 | — | — | US | disclosed |
| WO-2010040209-A1 | METHODS AND SYSTEMS FOR PREDICTING MISFOLDED PROTEIN EPITOPES | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2010-04-15 | — | — | WO | disclosed |
| US-7601516-B2 | Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility | Syntomix Pharmaceuticals, Inc. (US) | 2009-10-13 | — | — | US | disclosed |
| US-20070265365-A1 | Water Soluble Polymers Containing Vinyl Unsaturation, Their Crosslinking and Process for Preparation Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-11-15 | — | — | US | disclosed |
| EP-1828255-A1 | WATER SOLUBLE POLYMERS CONTAINING VINYL UNSATURATION, THEIR CROSSLINKING AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-09-05 | — | — | EP | disclosed |
| CN-1926237-A | Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility | SYNTONIX PHARMACEUTICALS INC (US) | 2007-03-07 | — | — | CN | disclosed |
| EP-1711610-A2 | HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY | SYNTONIX PHARMACEUTICALS, INC. (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2006046254-A1 | WATER SOLUBLE POLYMERS CONTAINING VINYL UNSATURATION, THEIR CROSSLINKING AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-05-04 | — | — | WO | disclosed |
| US-20050186662-A1 | Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility | SYNTONIX PHARMACEUTICALS, INC. (US) | 2005-08-25 | — | — | US | disclosed |
| WO-2005073383-A2 | HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY | SYNTONIX PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |
| US-20050171425-A1 | Medical devices having MRI-enhancing encapsulated fluids | PHANTOMS-BY-DESIGN (US) | 2005-08-04 | — | — | US | disclosed |