Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1069477 | 0.84 | ALDH1A1 (0.58) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Deanol SCHEMBL28088488 | 0.82 | LMNA (0.50) | LMNAMEN1KMT2AALOX15HSD17B10 | |
| Tromethamine SCHEMBL235150 | 0.81 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Tromethamine SCHEMBL29379456 | 0.81 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Tromethamine SCHEMBL3358691 | 0.81 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Tromethamine SCHEMBL30214902 | 0.81 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Tromethamine SCHEMBL4449265 | 0.81 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1TP53 | |
| Tromethamine SCHEMBL8668436 | 0.80 | LMNA (0.71) | LMNAMEN1KMT2AMAPK1 | |
| Tromethamine SCHEMBL9235516 | 0.80 | LMNA (0.71) | LMNAMEN1KMT2AMAPK1 | |
| Tromethamine SCHEMBL237361 | 0.80 | LMNA (0.71) | LMNAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117085520-A | Graphene oxide/polyvinylidene fluoride composite film and preparation method and application thereof | 昆明理工大学 | 2023-11-21 | — | — | CN | claimed |
| CN-117085520-A | Graphene oxide/polyvinylidene fluoride composite film and preparation method and application thereof | 昆明理工大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-116905012-A | Porous organic cage catalytic intermediate layer-containing bipolar membrane and preparation method and application thereof | 昆明理工大学 | 2023-10-20 | — | — | CN | disclosed |
| EP-1809731-B1 | RHEOLOGY MODIFIER/HAIR STYLING RESIN | ISP INVESTMENTS INC (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2013154845-A1 | CURABLE NAIL ENHANCEMENTS | ESSCHEM, INC. (US) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013103528-A1 | POLYMERS CONTAINING AN ACETOACETATE MOIETY | ISP INVESTMENTS INC. (US) | 2013-07-11 | — | — | WO | disclosed |
| WO-2008070368-A2 | METHODS AND COMPOSITIONS FOR SKIN CARE | LIVING PROOF, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
| EP-1809731-A4 | RHEOLOGY MODIFIER/HAIR STYLING RESIN | ISP INVESTIMENTS INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1809731-A2 | RHEOLOGY MODIFIER/HAIR STYLING RESIN | ISP Investiments Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1663117-A1 | COSMETIC COMPOSITIONS IN SINGLE PORTION PACKAGINGS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2006044193-A2 | RHEOLOGY MODIFIER/HAIR STYLING RESIN | ISP INVESTMENTS INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| WO-2004100901-A2 | COSMETIC COMPOSITIONS IN SINGLE PORTION PACKAGINGS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-11-25 | — | — | WO | disclosed |