Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159759 | 0.80 | PSIP1 (0.46) | PRSS1PRSS2PRSS3PSIP1 | |
| SCHEMBL21491104 | 0.76 | PSIP1 (0.32) | PRSS1PRSS2PRSS3PSIP1 | |
| SCHEMBL3540671 | 0.76 | PSIP1 (0.38) | PSIP1RIPK1MAPT | |
| SCHEMBL4602192 | 0.75 | KDM4E (0.31) | MAPT | |
| SCHEMBL11562313 | 0.75 | HSD11B1 (0.32) | PRSS1PRSS2PRSS3PSIP1MAPT | |
| SCHEMBL1014627 | 0.74 | ALDH1A1 (0.33) | PSIP1MAPT | |
| SCHEMBL11565035 | 0.74 | PSIP1 (0.36) | PRSS1PRSS2PRSS3PSIP1MAPT | |
| SCHEMBL7813681 | 0.73 | CA1 (0.47) | F2PRSS1PRSS2PRSS3MAPT | |
| SCHEMBL6623865 | 0.73 | PSIP1 (0.35) | PSIP1MAPT | |
| SCHEMBL6749727 | 0.73 | MAPK1 (0.41) | MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |
| US-4176184-A | CARDIOTONICS, HYPOTENSIVES, ANTITHROMBOTICS AND ANTIARRHYTHMICS | BOEHRINGER INGELHEIM GMBH (DE) | 1979-11-27 | — | — | US | disclosed |