SCHEMBL4602192

SCHEMBL4602192

COS(=O)(=O)c1[c]cccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
MAP2K7 O14733 1/20 0.31
GMNN O75496 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
CYP1A2 P05177 1/20 0.31
POLB P06746 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
MAPT P10636 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
CDC25A P30304 1/20 0.31
CDC25B P30305 1/20 0.31
CYP2C19 P33261 1/20 0.31
THPO P40225 1/20 0.31
MTOR P42345 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6030847 0.76 KMT2A (0.48) ALDH1A1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL77668 0.76 PTGS2 (0.33) POLB
SCHEMBL157674 0.75 L3MBTL1 (0.40) ALDH1A1LMNACYP1A2RAB9ASMN1; SMN2
SCHEMBL150811 0.75 HTR6 (0.38) KMT2A
SCHEMBL10695322 0.75 F2 (0.33) MAPT
SCHEMBL11841732 0.74 ALDH1A1 (0.43) ALDH1A1LMNACYP1A2CYP2C9HPGD
SCHEMBL8832250 0.74 LMNA (0.36) KDM4EALDH1A1LMNAPOLBMAPT
SCHEMBL8726863 0.73 KMT2A (0.35) KMT2A
SCHEMBL8387010 0.73 HTR6 (0.31)
SCHEMBL17674274 0.72 KEAP1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3452524-A1 WATER VAPOR-BLOCKING ADHESIVE COMPOUND HAVING HIGHLY FUNCTIONALIZED POLY(METH)ACRYLATE tesa SE (DE) 2019-03-13 EP disclosed
US-7462228-B2 Water-base black ink composition and colored product NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2008-12-09 US disclosed
EP-1602695-B1 WATER-BASE BLACK INK COMPOSITION AND COLORED MATERIAL NIPPON KAYAKU KK (JP) 2008-04-23 EP disclosed
US-20060144288-A1 Water-base black ink composition and colored material NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2006-07-06 US disclosed
EP-1602695-A1 WATER-BASE BLACK INK COMPOSITION AND COLORED MATERIAL Nippon Kayaku Kabushiki Kaisha (JP) 2005-12-07 EP disclosed
US-20020198244-A1 Heterocyclic aromatic oxazole compounds and use thereof HARUTA JUNICHI (JP) 2002-12-26 US disclosed
US-20020198245-A1 Heterocyclic aromatic oxazole compounds and use thereof HARUTA JUNICHI (JP) 2002-12-26 US disclosed
US-20020143040-A1 Heterocyclic aromatic oxazole compounds and use thereof HARUTA JUNICHI (JP) 2002-10-03 US disclosed
US-20020115701-A1 Heterocyclic aromatic oxazole compounds and use thereof HARUTA JUNICHI (JP) 2002-08-22 US disclosed
US-20020107271-A1 Heterocyclic aromatic oxazole compounds and use thereof HARUTA JUNICHI (JP) 2002-08-08 US disclosed
US-5049481-A Merocyanine compound FUJI PHOTO FILM CO., LTD. (JP) 1991-09-17 US disclosed
EP-0377321-A2 Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1990-07-11 EP disclosed
EP-0353692-A2 Drug effect-enhancing agent for antitumor drug NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1990-02-07 EP disclosed
EP-0109291-B1 PHOTOPOLYMERIZABLE COMPOSITION FUJI PHOTO FILM CO., LTD. (JP) 1987-03-04 EP disclosed
US-4481276-A ARGON LASER FUJI PHOTO FILM CO., LTD. (JP) 1984-11-06 US disclosed
US-4399211-A ACRYLIC OLIGOESTER, DIBASIC ACID, POLYOL AND PROMOTER FUJI PHOTO FILM CO., LTD. (JP) 1983-08-16 US disclosed
US-4367280-A AROMATIC CARBONYL COMPOUND AND P-DIALKYLAMINO AROMATIC CARBONYL COMPOUND COMBINATION POLYMERIZATION INITIATOR FUJI PHOTO FILM CO., LTD. (JP) 1983-01-04 US disclosed
US-4290870-A 5-ISOXOLONE, AROMATIC CARBONYL, DIALKYLAMINO AROMATIC CARBONYL OR FUJI PHOTO FILM CO., LTD. (JP) 1981-09-22 US disclosed
US-4224225-A PHOTOPOLYMERIZATION INITIATOR FUJI PHOTO FILM CO., LTD. (JP) 1980-09-23 US disclosed
US-4148658-A BENZOYLMETHYLENE-BENSOTHIAZOLYIDEND-THIAZOLIDONE COMPOUND, AMINE, AND AMINOARYLCARBONYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1979-04-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020198245-A1 Heterocyclic aromatic oxazole compounds and use thereof PTGS1, OXER1, HRH2 KDM4E 2283/4885MAP2K7 1109/4885GMNN 4794/4885
US-20020115701-A1 Heterocyclic aromatic oxazole compounds and use thereof PTGS1, OXER1, HRH2 KDM4E 2283/4885MAP2K7 1109/4885GMNN 4794/4885
US-20020143040-A1 Heterocyclic aromatic oxazole compounds and use thereof PTGS1, OXER1, HRH2 KDM4E 2283/4885MAP2K7 1109/4885GMNN 4794/4885
US-20060144288-A1 Water-base black ink composition and colored material RB1, CDK11B, CDK13 KDM4E 414/4885MAP2K7 3413/4885GMNN 2655/4885
US-20020198244-A1 Heterocyclic aromatic oxazole compounds and use thereof PTGS1, OXER1, HRH2 KDM4E 2283/4885MAP2K7 1109/4885GMNN 4794/4885
US-20020107271-A1 Heterocyclic aromatic oxazole compounds and use thereof PTGS1, OXER1, HRH2 KDM4E 2283/4885MAP2K7 1109/4885GMNN 4794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.