Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696897 | 0.81 | L3MBTL1 (0.51) | NPC1MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL2490128 | 0.79 | MAPT (0.61) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10698788 | 0.78 | MAPT (0.55) | TDP1NPC1MAPK1RAB9AALDH1A1 | |
| SCHEMBL5563212 | 0.78 | RECQL (0.42) | MPITDP1HTTMAPTHSPA9 | |
| SCHEMBL10693972 | 0.78 | NPC1 (0.41) | MPITDP1NPC1MAPK1RAB9A | |
| SCHEMBL10695938 | 0.76 | MAPT (0.52) | NPC1MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL10698508 | 0.76 | MAPT (0.53) | TDP1NPC1RAB9AALDH1A1HTT | |
| SCHEMBL2492692 | 0.75 | MPI (0.48) | MPITDP1ALDH1A1HTTHCAR3 | |
| SCHEMBL10711637 | 0.75 | NPC1 (0.48) | NPC1MAPK1RAB9AALDH1A1GLA | |
| SCHEMBL2486549 | 0.73 | MAPT (0.41) | NPC1MAPK1RAB9AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |