Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8997349 | 0.88 | ACHE (0.44) | ACHEKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8997331 | 0.88 | ACHE (0.44) | ACHEKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9397404 | 0.85 | ACHE (0.53) | ACHEKDM4EALDH1A1HPGDMEN1 | |
| Trifluoromethanesulfonic Acid SCHEMBL8332157 | 0.84 | ACHE (0.41) | ACHEKDM4EALDH1A1HPGDMEN1 | |
| Trifluoromethanesulfonic Acid SCHEMBL8332152 | 0.84 | ACHE (0.41) | ACHEKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL15056134 | 0.81 | TERT (0.48) | LMNATERTACHEKDM4EALDH1A1 | |
| SCHEMBL38661525 | 0.77 | KMT2A (0.40) | LMNAACHEKDM4EALDH1A1HPGD | |
| SCHEMBL29380978 | 0.74 | MAPT (0.41) | ACHEKDM4EHPGDSMN1; SMN2CYP1A2 | |
| Trifluoromethanesulfonic Acid SCHEMBL2996949 | 0.74 | ACHE (0.42) | LMNAACHECA12CA1CA2 | |
| SCHEMBL118743 | 0.74 | MAPT (0.41) | ACHEKDM4EHPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263657-A2 | Polysubstituted aryl acridinium esters | Ciba Corning Diagnostics Corp. (US) | 1988-04-13 | — | — | EP | disclosed |