Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 14/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693698 | 0.97 | KDM4E (0.40) | ALDH1A1KDM4EHSD17B10CYP19A1 | |
| SCHEMBL10696042 | 0.93 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10CYP19A1HPGD | |
| SCHEMBL10696613 | 0.90 | AURKA (0.40) | ALDH1A1KDM4EHSD17B10CYP19A1KMT2A | |
| SCHEMBL10698603 | 0.87 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL10696477 | 0.87 | KDM4E (0.42) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL10695087 | 0.87 | TNKS2 (0.44) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL10698037 | 0.86 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10MAPTTDP1 | |
| SCHEMBL10695491 | 0.84 | MAPT (0.42) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL10694215 | 0.82 | ELANE (0.46) | ALDH1A1KDM4EHSD17B10MAPTTDP1 | |
| SCHEMBL10695498 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |