Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696397 | 0.93 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10CYP19A1HPGD | |
| SCHEMBL10693698 | 0.92 | KDM4E (0.40) | ALDH1A1KDM4EHSD17B10CYP19A1 | |
| SCHEMBL10696613 | 0.92 | AURKA (0.40) | ALDH1A1KDM4EHSD17B10CYP19A1AURKA | |
| SCHEMBL10698603 | 0.89 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10AURKAAURKB | |
| SCHEMBL10698037 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KDM4EHSD17B10AURKAAURKB | |
| SCHEMBL10696318 | 0.86 | KDM4E (0.41) | ALDH1A1KDM4EHSD17B10KCNA5KCNJ5 | |
| SCHEMBL10694215 | 0.84 | ELANE (0.46) | ALDH1A1KDM4EHSD17B10PGRPDE4A | |
| SCHEMBL10696440 | 0.84 | MEN1 (0.40) | ALDH1A1HSD17B10CYP19A1AURKAAURKB | |
| SCHEMBL10695498 | 0.84 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10LMNAL3MBTL1 | |
| SCHEMBL10699508 | 0.81 | AURKA (0.39) | AURKAAURKBPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |