Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.62 |
| ▸ | BCHE | P06276 | 8/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249591 | 0.91 | ACHE (0.75) | ACHEBCHEBACE1KDM4EMEN1 | |
| SCHEMBL9253566 | 0.89 | ACHE (0.64) | ACHEBCHEBACE1KDM4EMEN1 | |
| SCHEMBL9257216 | 0.83 | ACHE (0.76) | ACHEBCHEBACE1KDM4EMEN1 | |
| SCHEMBL9258030 | 0.81 | ACHE (0.68) | ACHEBCHECYP1A2APP | |
| SCHEMBL9253349 | 0.81 | ACHE (0.58) | ACHEBCHEBACE1KDM4EMEN1 | |
| SCHEMBL9257120 | 0.81 | ACHE (0.60) | ACHEBCHEBACE1 | |
| SCHEMBL9259460 | 0.80 | ACHE (0.71) | ACHEBCHE | |
| SCHEMBL9259739 | 0.77 | ACHE (0.72) | ACHEMEN1HTTKMT2A | |
| SCHEMBL9250740 | 0.76 | ACHE (0.53) | ACHEBCHEHTTAPP | |
| SCHEMBL29062229 | 0.75 | ACHE (0.59) | ACHEBCHEBACE1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282959-A2 | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |