Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.68 |
| ▸ | BCHE | P06276 | 11/20 | 0.68 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259460 | 0.93 | ACHE (0.71) | ACHEBCHE | |
| SCHEMBL9255951 | 0.90 | ACHE (0.61) | ACHEBCHE | |
| SCHEMBL9249591 | 0.83 | ACHE (0.75) | ACHEBCHECYP1A2 | |
| SCHEMBL9253566 | 0.81 | ACHE (0.64) | ACHEBCHECYP1A2TSHR | |
| SCHEMBL10696834 | 0.81 | ACHE (0.62) | ACHEBCHEAPPCYP1A2 | |
| SCHEMBL9261162 | 0.81 | ACHE (0.65) | ACHEBCHEAPPCYP1A2TSHR | |
| SCHEMBL9259739 | 0.81 | ACHE (0.72) | ACHE | |
| SCHEMBL27397093 | 0.80 | ACHE (0.61) | ACHEBCHEAPPCYP1A2TSHR | |
| SCHEMBL9250740 | 0.80 | ACHE (0.53) | ACHEBCHEAPP | |
| SCHEMBL9255970 | 0.79 | ACHE (0.63) | ACHEBCHEAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391553-A | Increasing cholinergic functionin mammals | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0282959-A2 | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |