Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700609 | 0.89 | SCN9A (0.32) | AURKAAURKBKCNA5KCNJ5KCNJ3 | |
| SCHEMBL10695292 | 0.86 | PDE4A (0.38) | BRD4MEN1KMT2AADORA2ABACE1 | |
| SCHEMBL10700356 | 0.84 | AURKA (0.40) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10700217 | 0.82 | KDM4E (0.41) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10696613 | 0.81 | AURKA (0.40) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10699508 | 0.79 | AURKA (0.39) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10698038 | 0.78 | AURKA (0.40) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10696318 | 0.77 | KDM4E (0.41) | KCNA5KCNJ5KCNJ3MEN1KMT2A | |
| SCHEMBL10700532 | 0.77 | AURKA (0.43) | AURKAAURKBMARK3CHEK1SRC | |
| SCHEMBL10696042 | 0.76 | ALDH1A1 (0.39) | AURKAAURKBKCNA5KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |