Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697407 | 0.89 | AURKA (0.40) | AURKAAURKBKCNA5KCNJ5KCNJ3 | |
| SCHEMBL10695491 | 0.84 | MAPT (0.42) | SCN9ACNR2 | |
| SCHEMBL10693698 | 0.83 | KDM4E (0.40) | SCN9ACYP19A1CNR2 | |
| SCHEMBL10695292 | 0.82 | PDE4A (0.38) | ADORA2A | |
| SCHEMBL10696477 | 0.80 | KDM4E (0.42) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL10696397 | 0.80 | ALDH1A1 (0.40) | CYP19A1 | |
| SCHEMBL10696318 | 0.78 | KDM4E (0.41) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL10696042 | 0.77 | ALDH1A1 (0.39) | AURKAAURKBCYP19A1KCNA5KCNJ5 | |
| SCHEMBL10695201 | 0.75 | SCN9A (0.35) | SCN9ACNR2ADORA2B | |
| SCHEMBL10695114 | 0.75 | SCN9A (0.37) | SCN9ACNR2ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |