Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696042 | 0.92 | ALDH1A1 (0.39) | AURKAAURKBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10696397 | 0.90 | ALDH1A1 (0.40) | KDM4EALDH1A1HSD17B10GAAKMT2A | |
| SCHEMBL10693698 | 0.89 | KDM4E (0.40) | KDM4EALDH1A1HSD17B10CYP19A1 | |
| SCHEMBL10698603 | 0.88 | ALDH1A1 (0.39) | AURKAAURKBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10698037 | 0.87 | ALDH1A1 (0.38) | AURKAAURKBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10699508 | 0.87 | AURKA (0.39) | AURKAAURKBCHEK1SRCCDK2 | |
| SCHEMBL10700217 | 0.86 | KDM4E (0.41) | AURKAAURKBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10701198 | 0.86 | TNKS2 (0.44) | AURKAAURKBKDM4EALDH1A1GAA | |
| SCHEMBL10698519 | 0.85 | CNR1 (0.41) | AURKAAURKBALDH1A1CHEK1SRC | |
| SCHEMBL10698153 | 0.85 | AURKA (0.38) | AURKAAURKBCHEK1SRCCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |