Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697625 | 0.72 | BMPR1B (0.39) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL10699780 | 0.69 | BMPR1B (0.37) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL10697614 | 0.69 | CBFB (0.47) | PKMLMNASMN1; SMN2KDM4EGCK | |
| SCHEMBL10699776 | 0.68 | CA12 (0.44) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL578249 | 0.64 | HTR7 (0.54) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL30404097 | 0.64 | HTR7 (0.54) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL9831023 | 0.63 | PDK2 (0.38) | MAT2A | |
| SCHEMBL10472406 | 0.62 | OPRK1 (0.36) | POLBLMNASMN1; SMN2KDM4EHPGD | |
| SCHEMBL10701670 | 0.60 | NPC1 (0.48) | BRD4KDM4EHPGDHTTL3MBTL1 | |
| SCHEMBL14139369 | 0.60 | KMT2A (0.47) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |