Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSH | P09668 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.42 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838491 | 0.82 | CTSB (0.49) | CTSBCTSHALDH1A1S1PR4NFKBIA | |
| SCHEMBL10622390 | 0.78 | RELA (0.52) | CTSBCTSHALDH1A1S1PR4NFKBIA | |
| SCHEMBL20838507 | 0.77 | NFKBIA (0.53) | CTSBCTSHALDH1A1NFKBIARELA | |
| SCHEMBL8548121 | 0.75 | CTSB (0.60) | CTSBCTSHALDH1A1NFKBIARELA | |
| SCHEMBL20838508 | 0.75 | CTSB (0.52) | CTSBCTSHALDH1A1S1PR4NPC1 | |
| SCHEMBL10698059 | 0.75 | MAPT (0.54) | CTSBCTSHALDH1A1S1PR4RELA | |
| SCHEMBL230859 | 0.75 | RELA (0.59) | CTSBCTSHALDH1A1NFKBIARELA | |
| SCHEMBL10698493 | 0.74 | ALDH1A1 (0.47) | CTSBCTSHALDH1A1S1PR4NFKBIA | |
| SCHEMBL3557626 | 0.74 | HSP90AA1 (0.68) | CTSBALDH1A1RELANPC1MAPT | |
| SCHEMBL136263 | 0.73 | CTSB (0.53) | CTSBCTSHALDH1A1S1PR4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466931-B1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | UNIV GUANGDONG TECHNOLOGY (CN) | 2024-01-10 | — | — | EP | disclosed |
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | UNIV GUANGDONG TECHNOLOGY (CN) | 2020-10-20 | — | — | US | disclosed |
| EP-3466931-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | Guangdong University Of Technology (CN) | 2019-04-10 | — | — | EP | disclosed |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | GUANGDONG UNIVERSITY OF TECHNOLOGY | 2019-03-28 | — | — | US | disclosed |
| CN-105949120-A | Four-tooth chelating single quinoline derivative, preparation method thereof and application as metal ion regulator for neurodegenerative disease | 广东工业大学 | 2016-09-21 | — | — | CN | disclosed |
| EP-0282893-A2 | Pesticides based on 1,10-phenanthrolines | BAYER AG (DE) | 1988-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807957-B2 | Tetradentate chelating monoquinoline derivative, manufacturing method thereof, and application of same as metal ion regulator for neurodegenerative disease | SOD1, SLC30A6, SLC30A7 | CTSB 2368/4885CTSH 3784/4885ALDH1A1 1013/4885 |
| US-20190092730-A1 | TETRADENTATE CHELATING MONOQUINOLINE DERIVATIVE, MANUFACTURING METHOD THEREOF, AND APPLICATION OF SAME AS METAL ION REGULATOR FOR NEURODEGENERATIVE DISEASE | SOD1, SLC30A6, SLC30A7 | CTSB 2368/4885CTSH 3784/4885ALDH1A1 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.