Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 12/20 | 0.62 |
| ▸ | RAD52 | P43351 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD1 | P21728 | 3/20 | 0.60 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | DRD5 | P21918 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL560221 | 0.90 | KIF11 (0.68) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL8256027 | 0.89 | DRD2 (0.56) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL560237 | 0.88 | FPR2 (0.67) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL1070185 | 0.87 | FPR2 (0.71) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL31322328 | 0.87 | RAD52 (0.72) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL5801554 | 0.86 | FPR2 (0.70) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL1067508 | 0.86 | FPR2 (0.72) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL5803456 | 0.85 | FPR2 (0.69) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL5802453 | 0.85 | FPR2 (0.69) | FPR2RAD52DRD2DRD1HRH1 | |
| SCHEMBL5802291 | 0.85 | FPR2 (0.69) | FPR2RAD52DRD2DRD1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275143-B1 | Conjugates of perphenazine or fluphenazine with carboxylic acids | UNIV RAMOT (IL) | 2012-12-19 | — | — | EP | disclosed |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2012-12-06 | — | — | US | disclosed |
| US-8283381-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-10-09 | — | — | US | disclosed |
| US-8168628-B2 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-05-01 | — | — | US | disclosed |
| EP-1429844-B1 | CONJUGATE OF PERPHENAZINE AND GABA AND USES THEREOF | UNIV RAMOT (IL) | 2012-01-18 | — | — | EP | disclosed |
| US-7939525-B2 | Conjugated psychotropic drugs and uses thereof | BAR-ILAN UNIVERSITY (IL) | 2011-05-10 | — | — | US | disclosed |
| EP-2275143-A2 | Conjugated anti-psychotic drugs and uses thereof | Ramot at Tel Aviv University Ltd. (IL) | 2011-01-19 | — | — | EP | disclosed |
| US-20100204469-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-08-12 | — | — | US | disclosed |
| US-20100120755-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-05-13 | — | — | US | disclosed |
| US-20100063034-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. | 2010-03-11 | — | — | US | disclosed |
| US-20080108606-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2008-05-08 | — | — | US | disclosed |
| US-20070197514-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
| US-20070099977-A1 | Conjugated psychotropic drugs and uses thereof | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2007-05-03 | — | — | US | disclosed |
| EP-1727566-A2 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | Ramot at Tel Aviv University Ltd. (IL) | 2006-12-06 | — | — | EP | disclosed |
| EP-1429844-A4 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | UNIV RAMOT (IL) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005092392-A2 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-10-06 | — | — | WO | disclosed |
| US-20040242570-A1 | Conjugated psychotropic drugs and uses thereof | BAR-ILAN UNIVERSITY (IL) | 2004-12-02 | — | — | US | disclosed |
| EP-1429844-A2 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | Ramot at Tel Aviv University Ltd. (IL) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003026563-A9 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | UNIV RAMOT (IL) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003026563-A2 | CONJUGATED ANTI-PSYCHOTIC DRUGS AND USES THEREOF | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063034-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20040242570-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20070099977-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20100204469-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20100120755-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20080108606-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20070197514-A1 | Conjugated psychotropic drugs and uses thereof | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
| US-20120309748-A1 | CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF | SLC18A2, SLC6A3, SLCO1B3 | FPR2 2983/4885RAD52 4471/4885DRD2 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.