Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.56 |
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | DRD1 | P21728 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | HTR2B | P41595 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31104445 | 0.90 | DRD2 (0.62) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL1070098 | 0.89 | FPR2 (0.62) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL31104431 | 0.89 | DRD2 (0.59) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL13602784 | 0.88 | DRD2 (0.62) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL10084512 | 0.85 | DRD2 (0.66) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL13602783 | 0.85 | DRD2 (0.58) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL10084508 | 0.84 | DRD2 (0.67) | DRD2HRH1DRD3DRD1MAPT | |
| SCHEMBL31648578 | 0.84 | DRD2 (0.63) | DRD2HRH1DRD3DRD1MAPT | |
| Perphenazine 4-Aminobutyrate SCHEMBL8250036 | 0.84 | DRD2 (0.64) | DRD2HRH1DRD3DRD1MAPT | |
| Perphenazine 4-Aminobutyrate SCHEMBL29414098 | 0.83 | DRD2 (0.63) | DRD2HRH1DRD3DRD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150352-A1 | CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-06-13 | — | — | US | disclosed |
| US-20130150352-A1 | CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-06-13 | — | — | US | disclosed |
| US-8377929-B2 | Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-02-19 | — | — | US | disclosed |
| EP-1888120-B1 | NOVEL SALTS OF CONJUGATED PSYCHOTROPIC DRUGS AND PROCESSES OF PREPARING SAME | UNIV RAMOT (IL) | 2012-12-05 | — | — | EP | disclosed |
| US-20090298814-A1 | Novel salts of conjugated psychotropic drugs and processes of preparing same | RAMOT AT TEL AVIV UNIVERISTY LTD (IL) | 2009-12-03 | — | — | US | disclosed |
| US-20090298814-A1 | Novel salts of conjugated psychotropic drugs and processes of preparing same | RAMOT AT TEL AVIV UNIVERISTY LTD (IL) | 2009-12-03 | — | — | US | disclosed |
| WO-2006131923-A2 | NOVEL SALTS OF CONJUGATED PSYCHOTROPIC DRUGS AND PROCESSES OF PREPARING SAME | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298814-A1 | Novel salts of conjugated psychotropic drugs and processes of preparing same | SLC7A1, SLC6A2, SLC18A2 | DRD2 114/4885HRH1 1254/4885DRD3 127/4885 |
| US-20130150352-A1 | CRYSTALLINE FORMS OF THE TRI-MESYLATE SALT OF PERPHENAZINE-GABA AND PROCESS OF PRODUCING THE SAME | DPP4, GABBR1, SLC6A1 | DRD2 247/4885HRH1 1008/4885DRD3 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.