Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.49 |
| ▸ | XDH | P47989 | 2/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704319 | 0.84 | XDH (0.46) | PDE3BPDE3AXDHTBK1HPGD | |
| SCHEMBL10739815 | 0.71 | GPR119 (0.60) | PDE3BPDE3A | |
| SCHEMBL10703150 | 0.71 | PDE3B (0.55) | PDE3BPDE3AXDHTBK1 | |
| SCHEMBL10704316 | 0.69 | PDE3B (0.50) | PDE3BPDE3AXDHHPGD | |
| SCHEMBL10763921 | 0.67 | PDE3B (0.71) | PDE3BPDE3AXDHTBK1 | |
| SCHEMBL414489 | 0.67 | MAPK1 (0.55) | PDE3BPDE3AXDHMAPK1HPGD | |
| SCHEMBL20702814 | 0.67 | SLC6A5 (0.56) | PDE3BPDE3AXDHMAPK1HPGD | |
| SCHEMBL20702646 | 0.66 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL8867261 | 0.65 | XDH (0.66) | PDE3BPDE3AXDH | |
| SCHEMBL17134283 | 0.65 | XDH (1.00) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0172141-B1 | SUBSTITUTED PYRIDAZINONES, METHOD FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATION CONTAINING THESE COMPOUNDS AND THEIR USE | CIBA-GEIGY AG (CH) | 1988-12-07 | — | — | EP | disclosed |