Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276163 | 0.83 | CA14 (0.36) | HDAC3HDAC1HDAC2NCOR2KIF11 | |
| SCHEMBL7265609 | 0.78 | L3MBTL1 (0.46) | LTA4HL3MBTL1SLC7A5 | |
| SCHEMBL28131444 | 0.77 | L3MBTL1 (0.43) | SYKLTA4HHDAC3HDAC1HDAC2 | |
| SCHEMBL8174634 | 0.76 | KYNU (0.48) | SYKBACE1ALDH1A1 | |
| SCHEMBL8693309 | 0.75 | LTA4H (0.41) | SYKLTA4HSMN1; SMN2ABCB1L3MBTL1 | |
| SCHEMBL6648512 | 0.75 | ALDH1A1 (0.49) | SYKHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7575306 | 0.75 | SYK (0.50) | SYKSMN1; SMN2BACE1ALDH1A1 | |
| SCHEMBL1937057 | 0.75 | ABCB1 (0.46) | SYKLTA4HABCB1L3MBTL1ITGA4 | |
| SCHEMBL29077734 | 0.74 | L3MBTL1 (0.50) | SYKHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6559401 | 0.74 | CCR6 (0.44) | SYKLTA4HHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126974-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4568666-A | COLLAGENASE INHIBITORS, ANTIARTJRITIC AGENTS | G. D. SEARLE & CO. (US) | 1986-02-04 | — | — | US | disclosed |
| US-4511504-A | COLLAGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0126974-A1 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1984-12-05 | — | — | EP | disclosed |