Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 19/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295158 | 0.82 | SLC6A3 (0.35) | LMNASLC6A3 | |
| SCHEMBL10624853 | 0.71 | GABRA5 (0.46) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10624905 | 0.71 | SMN1; SMN2 (0.45) | FDPSSLC6A3GGPS1 | |
| SCHEMBL13412470 | 0.71 | ALDH1A1 (0.38) | LMNASLC6A3 | |
| SCHEMBL16716829 | 0.71 | PGK1 (0.45) | SLC6A3 | |
| SCHEMBL10622087 | 0.70 | FDPS (0.71) | FDPSLMNA | |
| SCHEMBL7157650 | 0.70 | FDPS (0.50) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10709303 | 0.67 | FDPS (0.50) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10624770 | 0.67 | FDPS (0.46) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL10706646 | 0.67 | FDPS (0.50) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170228-B1 | DIPHOSPHONIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1988-12-28 | — | — | EP | disclosed |
| US-4687767-A | Certain 1-hydroxyethane, 1,1-di-phosphonic acid derivatives useful in treating calcium metabolism disturbances | BOEHRINGER MANNHEIM GMBH (DE) | 1987-08-18 | — | — | US | disclosed |
| EP-0170228-A1 | Diphosphonic-acid derivatives, process for their preparation and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-02-05 | — | — | EP | disclosed |