Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | CTSS | P25774 | 2/20 | 0.63 |
| ▸ | CTSK | P43235 | 2/20 | 0.63 |
| ▸ | CTSB | P07858 | 1/20 | 0.63 |
| ▸ | FNTA | P49354 | 1/20 | 0.53 |
| ▸ | FNTB | P49356 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11795309 | 0.87 | CTSL (0.58) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL29918220 | 0.87 | CTSS (0.53) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL25977614 | 0.87 | CTSL (0.68) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL27350811 | 0.87 | CTSL (0.68) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL7392267 | 0.87 | CTSL (0.68) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL4576781 | 0.87 | CTSL (0.68) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL17770756 | 0.86 | CTSS (0.63) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL29308942 | 0.85 | CTSS (0.66) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL9336693 | 0.85 | CTSS (0.66) | CTSLCTSSCTSKCTSBFNTA | |
| SCHEMBL9338814 | 0.85 | CTSS (0.66) | CTSLCTSSCTSKCTSBFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315963-B | LSH series cyclic pentapeptide ester and synthetic method and application thereof | 河北科技大学 | 2023-11-17 | — | — | CN | disclosed |
| CN-114315963-A | LSH series cyclic pentapeptide ester and synthetic method and application thereof | 河北科技大学 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021236475-A1 | COMPOUNDS THAT INHIBIT ASPARAGINE SYNTHETASE AND THEIR METHODS OF USE | ASINEX CORPORATION (US) | 2021-11-25 | — | — | WO | disclosed |
| WO-2021027744-A1 | 3-HYDROXY-5-PREGNANE-20-ONE DERIVATIVE AND USE THEREOF | 南京诺瑞特医药科技有限公司 | 2021-02-18 | — | — | WO | disclosed |
| US-9839665-B2 | Aminostatin derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2017-12-12 | — | — | US | disclosed |
| US-9839665-B2 | Aminostatin derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2017-12-12 | — | — | US | disclosed |
| EP-2673287-B1 | AMINO STATIN DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2017-08-30 | — | — | EP | disclosed |
| US-20160228493-A1 | AMINOSTATIN DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| US-20160228493-A1 | AMINOSTATIN DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | US | disclosed |
| US-9345742-B2 | Aminostatin derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2016-05-24 | — | — | US | disclosed |
| US-9345742-B2 | Aminostatin derivatives for the treatment of arthrosis | MERCK PATENT GMBH (DE) | 2016-05-24 | — | — | US | disclosed |
| EP-0126974-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4568666-A | COLLAGENASE INHIBITORS, ANTIARTJRITIC AGENTS | G. D. SEARLE & CO. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0126974-A1 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1984-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228493-A1 | AMINOSTATIN DERIVATIVES FOR THE TREATMENT OF ARTHROSIS | CTSD, CTSB, CTSZ | CTSL 4/4885CTSS 8/4885CTSK 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.