SCHEMBL10708127

SCHEMBL10708127

CC(O)COc1ccc(-c2ccc(C#N)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.66
HPGD P15428 2/20 0.66
MMP2 P08253 8/20 0.62
MMP3 P08254 7/20 0.62
LMNA P02545 1/20 0.55
KDM4E B2RXH2 3/20 0.53
MAPK1 P28482 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HSD17B10 Q99714 1/20 0.51
KDM1A O60341 1/20 0.48
MAPT P10636 1/20 0.48
HIF1A Q16665 1/20 0.48
MMP1 P03956 1/20 0.48
MMP9 P14780 1/20 0.48
MMP13 P45452 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30102507 0.95 LMNA (0.60) ALDH1A1HPGDMMP2MMP3LMNA
SCHEMBL25484191 0.95 LMNA (0.60) ALDH1A1HPGDMMP2MMP3LMNA
SCHEMBL29113764 0.95 LMNA (0.60) ALDH1A1HPGDMMP2MMP3LMNA
SCHEMBL9924742 0.86 MMP2 (0.61) ALDH1A1HPGDMMP2MMP3LMNA
SCHEMBL3274914 0.83 MMP2 (0.59) ALDH1A1HPGDMMP2MMP3KDM4E
SCHEMBL3274920 0.83 MMP2 (0.59) ALDH1A1HPGDMMP2MMP3KDM4E
SCHEMBL7554684 0.82 ALDH1A1 (0.64) ALDH1A1HPGDMMP2MMP3KDM4E
SCHEMBL21386579 0.81 MMP2 (0.57) ALDH1A1HPGDMMP2MMP3KDM4E
SCHEMBL9146899 0.81 MMP2 (0.57) ALDH1A1HPGDMMP2MMP3KDM4E
SCHEMBL91873 0.81 MMP2 (0.57) ALDH1A1HPGDMMP2MMP3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0171794-B1 ALCOHOL DERIVATIVES AND LIQUID CRYSTAL COMPOSITION CONTAINING THEM Chisso Corporation (JP) 1988-06-22 EP disclosed
US-4654162-A Alcohol derivatives CHISSO CORPORATION (JP) 1987-03-31 US disclosed
EP-0171794-A1 Alcohol derivatives and liquid crystal composition containing them Chisso Corporation (JP) 1986-02-19 EP disclosed