Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 5/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 5/20 | 0.35 |
| ▸ | MMP14 | P50281 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083304 | 0.70 | PIN1 (0.37) | PIN1 | |
| SCHEMBL6642020 | 0.70 | MAPT (0.50) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL312896 | 0.66 | SMN1; SMN2 (0.41) | LMNA | |
| SCHEMBL12463242 | 0.66 | LMNA (0.53) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL15028526 | 0.66 | LMNA (0.53) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL1070811 | 0.65 | ROCK2 (0.40) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL13956904 | 0.62 | MMP1 (0.54) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL13649413 | 0.62 | MMP1 (0.54) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL13686129 | 0.62 | MMP1 (0.54) | MMP1MMP3TACR3MMP2MMP9 | |
| SCHEMBL8816338 | 0.62 | PIN1 (0.43) | LMNAPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |