Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.31 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072632 | 0.85 | SMN1; SMN2 (0.36) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12934499 | 0.80 | P2RX3 (0.39) | PDE4BPDE4APDE4CPDE4DEHMT2 | |
| SCHEMBL2427449 | 0.80 | PIK3CD (0.38) | PDE4BPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1073873 | 0.80 | PDE4B (0.35) | PDE4BPDE4APDE4CPDE4DSTING1 | |
| SCHEMBL1071232 | 0.75 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3496077 | 0.75 | STING1 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGERBB2 | |
| Hydrochloric Acid SCHEMBL1071132 | 0.75 | HTR3E (0.37) | PIK3CDPIK3CAPIK3CBPIK3CGERBB2 | |
| Hydrochloric Acid SCHEMBL1071700 | 0.74 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1274041 | 0.74 | ACACB (0.34) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1072461 | 0.73 | SMN1; SMN2 (0.35) | PDE4BPDE4APDE4CPDE4DEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110002884-A1 | THERAPEUTIC COMPOUNDS | MERCK SHARP & DOHME LLC | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110002884-A1 | THERAPEUTIC COMPOUNDS | RRP1B, ZC3HAV1, RNASE1 | PDE4B 3086/4885PDE4A 3218/4885PDE4C 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.